Scientific References

Updated 12th August, 2025 

 

PubMed (2016) - Study

 

  • "A separate 12-week RCT demonstrated that taVNS significantly reduced anxiety scores compared to sham ()."

 

Frontiers in Neurology (2024) - Study

 

  • "We observed significant improvements across cognitive performance, mood (anxiety and depression), sleep, and fatigue following 10 days of t-VNS."  

 

JAMA Network (2024) - Study

 

  • "These findings establish that taVNS not only alleviated insomnia symptoms but also alleviated accompanying symptoms of anxiety, depression, and fatigue."

 

PubMed (2024) - Study

 

  • "All 60 patients showed improvements in anxiety, depression, and quality of life"

PubMed (2024) - Study

 

  • "VNS decreased VAS pain score and improved anxiety and depression."

 

PubMed (2024) - Study

 

  • "3 weeks of taVNS treatment could reverse depressive‐ and anxiety‐like behaviors in both adolescence and adulthood."

 

JMIR (2025) - Study

 

  • "Preliminary clinical studies have demonstrated VNS's therapeutic applications to treatment-resistant anxiety disorders"

 

Research Gate (2007) - Study

 

  • "In clinical studies, 1/2 identified potential anxiolytic effects in generalized anxiety..."

 

PubMed (2022) - Study

 

  • "Vagus nerve stimulation shows promise in simultaneously enhancing consolidation of extinction memories and reducing anxiety."

 

PubMed (2025) - Study

 

  • "patients in Group 2 showed significantly greater improvement in balance, dizziness, fatigue, kinesiophobia, anxiety, and depression."

 

PubMed (2018) - Study

 

  • "less anxiety (p = 0.08), occurred after stimulation."

 

DovePress (2025) - Study

 

  • "Existing studies have shown that taVNS can improve sleep quality, quality of life and the accompanying negative emotions."

 

PubMed (2014) - Study

 

  • "taVNS significantly improved sleep quality, insomnia severity, and overall quality of life compared to sham."

 

PubMed (2023) - Study

 

  • "Subjects receiving taVNS achieved a significantly greater reduction in their pain and fatigue compared with the sham group, and these effects remained during the whole study period."

 

PubMed (2023) - Study

 

  • "taVNS decreased VAS pain score and improved anxiety and depression. Compared with sham stimulation, the VAS pain score was decreased by 64% after taVNS treatment."

 

PubMed (2023) - Study

 

  • "Studies suggest taVNS can significantly decrease headache days in chronic migraine patients, with 1 Hz stimulation showing a more profound effect than 25 Hz. It also reduced migraine attack times and pain intensity."